威尼斯赌场

教授名录

www.dwlykj.com  www.wendehg.com  www.gcwlsb.com  www.zgxcled.com 

张坤

动物遗传育种学科

返回顶部基本信息

姓 名

张坤

职 称

研究员

导师类别

博士生导师

招生方向

物早期胚胎发育, 动物表观遗传学, 动物基因编辑

联系方法

电话

0571-88982506

Email

kzhang@zju.edu.cn

   

个人网页链接:mypage.zju.edu.cn/zhangkun/0.html

实验室网页链接:dairyscience.zju.edu.cn/index2.html 

 


教育与工作经历


20009-20047  本科毕业于中国农业大学动物科技学院

20049-20077 研究生,中国农业大学生物学院李宁教授实验室

20078-20117  博士,美国佛罗里达大学动物科学系

20117-20137  博士后,美国马萨诸塞大学兽医及动物科学系

20138-20157助理教授,美国密歇根州立大学动物科学系

研究领域和兴趣

主要从事动物生殖生物学、细胞和胚胎工程相关的应用基础研究,尤其关注哺乳动物早期胚胎发育调控机制的研究。

学术职位

国际生殖生物学协会会员(Society for the Study of Reproduction, Full member

国际胚胎移植大会会员(International Embryo Transfer Society

中国畜牧兽医学会动物繁殖学分会理事

在线威尼斯赌场澳门,澳門威尼斯赌场学报《农业与生命科学版》编委

主要获奖情况

  1. Lalor Foundation Merit Award

  2. Trainee Research Award Finalist 

  3. Larry Ewing Memorial Trainee Travel Fund (LEMTTF) from SSR (20112012)

  4. USDA NIFA NRI Merit Award from SSR 

  5. 国家优秀自费留学生奖学金 

  6. 2008年度,参与完成的成果“体细胞克隆猪和转基因体细胞克隆猪技术平台的建立与应用”,获得神农中华农业科技奖一等奖(第十五完成人)

  7. 佛罗里达大学校友奖学金 

发表文章

  1. Zhang K(通讯), Wang H, Rajput SK, Folger JKand Smith GW.Characterization of H3.3 and HIRA expression and function in bovine early embryos. Molecular Reproduction and Development. 2018 Feb; 85(2):106-116.

  2. Wallingford MC, Hiller J, Zhang K, Mager J. YY1 is required for post-transcriptional stability of SOX2 and OCT4 proteins. Cellular Reprogramming. 2017 Aug;19(4):263-269.

  3. Ding B#, Cao ZB#, Hong RY, Li H, XY Zuo, Luo L, Li YS, Huang WP, Li WY, Zhang K(通讯)and Zhang YH(通讯). WDR5 in porcine preimplantation embryos: expression, regulation of epigenetic modifications and requirement for early development. Biology of Reproduction. 2017 Apr 1;96(4):758-771. (# equal contribution)

  4.  Hand JM, Zhang K, Wang L, Koganti PP, Mastrantoni K, Rajput SK, Ashry M, Smith GW, Yao JB. Discovery of a novel oocyte-specific Krüppel-associated box domain-containing zinc finger protein required for early embryogenesis in cattle. Mechanisms of Development. 2017 Apr;144(Pt B):103-112.

  5.  Cui W, Dai XP, Marcho C, Han ZB, Zhang K, Tremblay K, and Mager J . Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Scientific Reports. 2016 Nov 21;6:37396.

  6. Zhang K(通讯), Rajput SK, Wang SH, Folger JK, Knott JG, and Smith GW. CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development. Biology of Reproduction. 2016 Oct;94(6):140

  7.  Yang QE, Ozawa Manabu, Zhang K, Johnson SE, Ealy AD. The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development.Reproduction, Fertility and Development, 2016 Mar;28(4):482-90.

  8.  Wang SH, Zhang K(通讯), Dai YP(通讯). Advances in genetic engineering of domestic animals. Frontiers of Agricultural Science and Engineering. 2016 March; 3(1):1-10; Cover Picture

  9.  Cui WPizzollo JHan ZMarcho CZhang KMager J.Nop2 is required for mammalian preimplantation development. Molecular Reproduction and Devevlopment. 2016 Feb;83(2):124-31.

  10. Zhang K, Rajput SK, Lee KB, Wang DL, Huang JC, Folger JK, Knott JG, Zhang JZ, and Smith GW. Evidence Supporting a Role for SMAD2/3 in Bovine Early Embryonic Development: Potential Implications for Embryotropic Actions of Follistatin. Biology of Reproduction. 2015 Oct;93(4):86

  11. Zhang K(通讯)and Smith GW. Maternal control of early embryogenesis in mammals. Reproduction, Fertility and Development. 2015 27(6) 880-896

  12.  Ashry M, Lee KB, Mondal M,  Datta TK, Folger JK, Rajput SK, Zhang K, Hemeida NAand Smith GW. Expression of TGFβ superfamily components and other markers of oocyte quality in oocytes selected by brilliant cresyl blue staining: Relevance to early embryonic development. Molecular Reproduction and Devevlopment 2015 Mar;82(3):251-64.

  13. Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, and Papaioannou VE. Mga is essential for the survival of pluripotent cells during peri-implantation development. Development 2015 142:31-40

  14. Lee KB#, Zhang K#, Folger JK, Knott JG, Smith GW. Evidence supporting a functional requirement of SMAD4 for bovine preimplantation embryonic development: A potential link to embryotropic actions of follistatin.Biology of Reproduction. 2014, 91(3):62 (# equal contribution)

  15. Lee KB, Wee G, Zhang K, Folger JK, Knott JG, Smith GW. Functional role of the bovine oocyte-specific protein JY-1 in meiotic maturation, cumulus expansion and subsequent embryonic development. Biology of Reproduction 2014 Mar 27;90(3):69

  16. Zhang K, Dai X, Trask MC and Mager J. Depletion of Suds3 reveals an essential role in early lineage specification. Developmental Biology, 373(2):359-72 (2013) Cover picture

  17. Zhang K, Harversat JM, Mager J. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Developmental Biology, 383(1):15-27 (2013).

  18. Zhang K, Ealy AD. Disruption of FGF signaling in COCs impacts oocyte maturation and developmental competence in vitro. Domestic Animal Endocrinology, 42(4):230-8 (2012)

  19. Zhang K, Ealy AD. Supplementing fibroblast growth factor 2 during bovine in vitro maturation promotes subsequent embryonic development. Open Journal of Animal Sciences, 2(2): 119-26 (2012)

  20. Zhang K, Hansen PJ, Ealy AD. Fibroblast growth factor 10 enhances bovine oocyte maturation and developmental competence in vitro. Reproduction 140: 815-826 (2010)

  21. Yang QE, Fields SD, Zhang K, Ozawa M, Johnson SE and Ealy AD. FGF2 promotes primitive endoderm development in bovine blastocysts. Biology of Reproduction 85(5):946-53 (2011)  

  22. Zhang K, Ma YF, Wang SH, Lou YK, Wei HX, Sun XZ, Sun GJ, Zhao YH, Li Y, Dai YP, Zhang L, Li N. Effects of Leptin supplementation in in vitro maturation medium on meiotic maturation of oocytes and preimplantation development of parthenogenetic and cloned embryos in pigs. Animal ReproductionScience 101(1-2):85-96 (2007)

  23. Zhang K, Wei HX, Zhang YH, Wang SH, Li Y, Dai YP and Li N. Effects of Ghrelin on in vitro development of porcine in vitro fertilized and parthenogenetic embryos. Journal of Reproduction and Development 53(3):647-53 (2007)

  24. Zhang K, Zhang YH, Pan DK, Ma YF, Wei HX, Zhang J, Li XY, Wang SH, Li Y, Dai YP and Li N. Seasonal influence on the development of parthenotes and cloned embryos in pigs. Progress in Natural Sciences 17(10): 1172-1176 (2007)

  25. Wang SH, Zhang K, Ding FR, Zhao R, Li S, Li R, Xu LL, Song C, Dai YP, and Li N. A novel promoterless gene targeting vector to efficiently disrupt prnp gene in cattle.Journal of Biotechnology163(4):377-85 (2013)

  26. Wang SH, Lv XQ, Zhang K, Lin TH, Liu XF, Yuan J, Dai YP, Li N. Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells. Molecular Biology Report37:3193–3198 (2010)

  27. Ma YF, Li Y, Wei HX, Li QY, Fang R, Zhao R, Zhang K, Xue K, Lou YK, Dai YP, Lian LS and Li N. Effects of chemical activation and season on birth efficiency of cloned pigs. Science in China C: Life Sciences 52(7):657-64 (2009)

  28. Wang SH; Sun XZ; Ding FR; Zhang K; Zhao R; Li S; Tang B; Li R; Zhang L; Liu Y; Li J; Gao FL; Wang HP; Wang LL; Dai YP, Li N. Removal of selectable marker gene from fibroblast cells in transgenic cloned cattle by transient expression of CRE recombinase and subsequent effects on recloned embryo development.Theriogenology 72(4): 535-541 (2009)

  29. Wei HX, Zhang K, Ma YF, Li Y, Li QY, Dai YP and Li N. Stage-dependent effect of Leptin on development of porcine embryos derived from parthenogenetic activation and transgenic somatic cell nuclear transfer.Journal of Reproduction and Development55(2):99-104 (2009)

  30.  Dang YN, Zhang K(通讯). Factors affecting early embryonic development in cattle: relevance for bovine cloning. Frontiers of Agricultural Science and Engineering. Accepted.

  31. 王少华,赵盼盼,刘通,丁彪,罗磊,曹祖兵,张运海,张坤(通讯).利用CRISPR/Cas9n技术生产抗蓝耳病的基因编辑克隆猪. 在线威尼斯赌场澳门,澳門威尼斯赌场学报(农业与生命科学版).已接受

  32. 王涵,赵盼盼,张坤(通讯). 哺乳动物着床前胚胎中细胞系的分化以及调控机制. 在线威尼斯赌场澳门,澳門威尼斯赌场学报(农业与生命科学版).已接受