威尼斯赌场

教授名录

www.dwlykj.com  www.wendehg.com  www.gcwlsb.com  www.zgxcled.com 

彭金荣

动物遗传育种学科

返回顶部基本信息

彭金荣
职 称
教授
功能基因组实验室主任
导师类别
博士生导师
招生方向
动物遗传育种与繁殖
联系方法
电话
0571-88982233
Fax
 
Email
pengjr@zju.edu.cn

返回顶部教育背景与工作简历

主要学习经历:

1990-1993年: 英国John Innes Centre,博士学位(University of East Anglia)

1984-1987年: 中科院上海生物化学研究所, 硕士学位

1980-1984年: 四川大学生物系,学士学位



主要科研教学经历:

2008年-现在:在线威尼斯赌场澳门,澳門威尼斯赌场威尼斯赌场,教授

2005-2008年: 新加坡细胞分子生物所,功能基因组学实验室主任,资深科学家(Principal Investigator/Senior Scientist)

2002-2005年: 新加坡细胞分子生物所,功能基因组学实验室主任(资深)(Senior Principal Investigator)

1999-2002年: 新加坡农业分子生物所, 功能基因组学实验室主任 (Principal Investigator)

1993-1999年: 英国John Innes Centre,博士后

1990-1993年: 英国John Innes Centre,博士

1987-1990年: 复旦大学生物化学系,助教
 

返回顶部学术兼职


 

返回顶部所获荣誉与主要奖励

2009年:入选首批‘国家千人计划’

2008年:获国家基金委‘国家杰出青年基金’

2008年:获聘教育部‘长江特聘教授’

2007年:获国家基金委‘海外及港澳学者合作研究基金’(海外杰青)

1990年:获教育部中英友好奖学金
 

返回顶部研究领域

    

研究领域一、以斑马鱼为模式材料研究肝脏发育和再生的分子调控机制;
研究领域二、以拟南芥为模式材料研究植物激素赤霉素信号传导及DELLA基因的功能。
 
一、在肝脏发育分子机理研究方面的贡献
肝脏是体内最重要的器官之一,主管代谢,解毒及体液平衡。然而,对于肝脏早期发育的分子机制却知之甚少。自2000年起彭金荣实验室利用斑马鱼开展功能基因组学及有关肝脏及其它消化道器官(如胰腺体,肠)早期发育的研究在斑马鱼发育研究领域以通讯或共同通讯作者发表了24篇系列论文(Genes & Development 两篇, Cell Research两篇, Genome Research 一篇, PLoS Biology一篇,PLoS Genetics一篇,Development 一篇, Nucleic Acid Research 一篇,Blood 一篇, Developmental Biology 两篇, JBC一篇等期刊)。
 
主要贡献
2003年,我们一直围绕肝脏发育突变体def-/-开展深入研究,研究结果首次证明在核仁中存在一个由Def-Calpain3 为轴心的介导蛋白降解的新途径来调控细胞增殖与死亡,并由此调控肝脏的发育。该研究成果拓宽了我们对核仁生物学功能的理解,同时为细胞生物学和发育生物学开辟新了研究方向。
1)、通过研究def-/-突变体发现了抑癌基因p53的异构体Δ113p53p53异构体的发现被誉为p53领域近10内最重要的进展之一。同时发现Def通过调控p53Δ113p53来控制斑马鱼消化器官的发育。该研究结果2005年发表在美国的《Genes & Development》杂志上。
2)、进一步的研究证明Δ113p53是一个新基因,它的转录表达直接受p53调控,而其功能是选择性地拮抗p53的促凋亡功能。基于这项工作我们提出了一个新的调控p53功能的p53-Δ113p53负反馈调控途径,并已被其它研究组在人细胞研究中获得证明。该研究成果在肿瘤研究领域开辟了新方向。该项工作2009年发表在《Genes & Development(封面论文,同期有专评)
彭金荣实验室与合作实验室进一步研究了p53的异构体Δ113p53/Δ133p53的生物学功能,发现Δ113p53/Δ133p53直接参与激活DNA双链断裂修复关键基因的表达,从而解决了长期困扰本领域有关p53如何参与DNA双链断裂修复的疑惑。该项工作已被Cell Rsearch正式接受。
3)、进一步的研究发现Def与半胱氨酸蛋白酶Calpain3形成复合体介导p53在核仁中的降解。该项工作成果分别于2013年发表在Cell Research》(封面论文,同期有专评)、2016年在《PLoS Biology》。
 
其它贡献:
1)、在EMBO数据库中注存了约31,000斑马鱼EST,共代表约17 ,000 unigene。这组ESTSanger Centre选中的两组用于预测斑马鱼基因组所编码的基因的EST组之一,为斑马鱼的功能基因组研究作出了极大贡献。该研究2003年发表在美国的《Genome Research》杂志上,并已向超过100多个来自世界各地的科研组提供斑马鱼EST克隆。(至2015.1.2185次)
2)、通过遗传突变、突变体筛选、基因克隆和功能分析,彭金荣实验室对一系列影响肝脏及其它消化器官早期发育的突变体进行了研究,研究结果分别发表在《Development》(2008年)(同期有专评)Developmental Biology》(2012年)、JGG》(封面论文)2012)以及PLoS Genetics2016)等专一期刊上。同时,彭金荣实验室还鉴定了斑马鱼成鱼肝脏中富集的129个基因,发现其中69个基因富集于斑马鱼胚胎期肝脏中。该工作为今后研究肝脏发育打下了坚实的基础。该项工作2006年发表在Development Biology》杂志上。
 
二、在赤霉素信号传导及DELLA基因功能研究方面的贡献
赤霉素是一种重要的植物激素,对植物生长发育起关键的调节作用。自1990年彭金荣在该领域开展了系统的研究工作。以通讯作者或共同通讯作者或第一作者在重要的学术刊物上(Nature, Science, Genes & Development, Plant Cell, Development, Plant J, Plant Physiology)发表了18篇有重要影响的论文,并根据他们的工作提出了广为接受的赤霉素去抑制生长的作用机制,这个理论主导了目前人们对赤霉素信号传导的研究,为人们认识赤霉素作用的分子机制作出了重要贡献。值得一提的是该理论已成为植物生理学教科书中赤霉素信号传导章节的重要组成(Plant Physiology, Fifth Edition, Lincoln Taiz& Eduardo Zeiger, 2010)。
 
1)、克隆了拟南芥中半显性矮杆基因gai(首个DELLA基因)。首次提出gai及其同源基因是植物生长的抑制因子。赤霉素通过解除这些抑制因子的功能而促进植物生长。该研究1997年发表在Genes & Development
 
2)、通过比较基因组学方法克隆了小麦半显性矮杆基因RhtRht又被称作小麦‘绿色革命基因’目前世界上超过90%的栽培小麦品种带有Rht基因),同时克隆了玉米中半显性矮秆基因D8。证明小麦绿色革命基因”Rht及玉米半显性矮秆基因D8是拟南芥半显性矮秆基因gai的同源基因。该工作从在分子水平上揭示了小麦‘绿色革命基因’的本质。该研究1999年发表在Nature
 
3)、gaiRhtD8等基因的克隆及他们所提出的去抑制生长机制主导了目前研究人员对赤霉素信号传导的研究。
 
4)、发现gai的同源基因RGL2是拟南芥中作为赤霉素信号传导的主要负调控因子来调节种子萌发。该研究加深了我们对赤霉素是如何调节种子萌发的理解。研究2002年结果发表在《Genes & Development》(Nature Review Genetics有专评)。
 
5)发现RGL2及其它两个同源基因RGARGL1是拟南芥中作为赤霉素信号传导的负调控因子主控花瓣及雄蕊的发育。该研究2004年发表在《Development》。发现赤霉素通过促进另一个植物激素茉莉素的合成来调控MYB基因的表达来控制花丝的生长。该研究2009年发表在PLoS Genetics。作为协作实验室参与发现了DELLA家族基因在植物主动抗逆(如抗盐)过程中的重要作用,研究结果2006年发表在Science》。此外,彭金荣还发表了其他一系列与赤霉素有关的研究论文,为人们认识赤霉素作用的分子机制作出了重要的贡献。

 

返回顶部完成及现有课题


 

返回顶部学术论文

 
通讯或共同通讯作者论文:
1. Gong, L., Pan, X.,Chen, H.D., Rao, L.J., Zeng, Y.L., , Huang, H.H., Peng, J.R.,* Xiao, L.,* Chen, J.* (2016) p53 isoform Δ133p53 promotesefficiency of induced pluripotentstem cells and ensures genomicintegrity during reprogramming. Scientific Reports6:37281, DOI: 10.1038/srep37281.
 
2. Guan, Y.H., Huang, D.L., Chen, F., Gao, C., Tao, T., Shi, H., Zhao, S.Y., Liao, Z.Y., Lo, L.J., Wang, Y.C., Chen, J., Peng, J.R. (2016) Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell-cycle Progression through Def Recruitment of Calpain3. PLoSBiol14(9): e1002555.
 
3.Hu, M.J., Bai, Y., Zhang, C.X., Liu, F., Cui, Z.B., Chen, J.,* Peng, J.R.* (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish.PLoS Genetics 12(2): e1005881.
 
4. Guan, Y.H., Zhu, Q.F., Huang, D.L., Zhao, S.Y., Lo, L.J., Peng, J.R.* (2015) An equation to estimate the difference between theoreticallypredicted and SDS PAGE-displayedmolecular weights for an acidicpeptide. Scientific Reports5:13370, DOI: 10.1038/srep13370
 
5. Chen, J., Peng, J.R. (2015) Δ113p53/Δ133p53: survival and integrity. Oncotarget 6(16):13850-13851. (Editorial) 
 
6. Gong, L.,Gong, H.J., Pan, X., Chang, C.Q., Ou, Z., Ye, S.F., Yin, L., Yang, L.N., Tao, T., Zhang, Z.H., Liu, C., Lane, D.P., Peng, J.R.,* Chen, J.* (2015) p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Research25(3):351-369.
 
7. Shi, H., Tao, T., Huang D.L., Ou, Z., Chen, J.*, Peng, J.R.* (2015) A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function. Nucleic Acids Res43(2):1035–1043. (Faculty1000 Prime)
 
8. Zhu, Z.H., Chen, J., Xiong, J.W., Peng, J.R.* (2014) Haploinsufficiency of Def activates p53-dependent TGFβ signalling and causesscar formation after partial hepatectomy. PLoS ONE 9(5):e96576
 
9. Niu, X.B., Hong, J.,Zheng, X.F., Melville, D.B., Knapik, E.W., Meng, A.M., Peng, J.R.* (2014) Thenuclear pore complex function of Sec13 is required for cell survival during retinal development. J BiolChem289:11971-11985.
 
10. Ou, Z., Yin, L.,Chang, C.Q.,Peng, J.R.,*Chen, J.*(2014) Protein interaction between p53 andΔ113p53 is required for theanti-apoptotic function ofΔ113p53.Journal of Genetics and Genomics 41:53-62.
 
11. Tao, T., Shi, H., Huang, D.L., Peng, J.R.*(2013) Def functions as a cell autonomous factor in organogenesis of digestive organs in zebrafish. PLoS ONE 8(4):e58858.
 
12. Tao, T., Shi, H., Guan, Y.H., Huang, D.L., Chen, Y., Lane, D.P.L.*, Chen, J.*, Peng, J.R.* (2013) Def definesaconserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Research23:620-634.
 
13. Wu, T., Zhang, Z.H., Yuan, Z.Q., Lo, L.J., Chen, J., Wang, Y.Z., and Peng, J.R. (2013) Distinctive genes determine different intramuscular fat and muscle fiber ratios of the longissimus dorsimuscles in Jinhua and Landrace pigs. PLoS ONE8(1):e53181.
 
14. Peng, J.R.*, Zhang, J., Meng, A.M. (2012) The tiny zebrafish keep swimming fast in the developmentalbiology pond. Journal of Genetics and Genomics 39:419-420.
 
15. Liu, J.G., Gong, L., Chang, C.Q., Liu, C., Peng, J.R.*, Chen, J.* (2012) Development of novel visual-plus quantitative analysis systems for studying DNA double-strand break repairs in zebrafish.Journal of Genetics and Genomics 39:489-502.
 
16. Wang, Y., Luo, Y., Hong, Y.H.*, Peng, J.R.*, Lo, L.J.* (2012) Ribosome biogenesis factor Bms1-like is essential for liver development in zebrafish. Journal of Genetics and Genomics 39:451-462.
 
17. Chen, M.X., Du, X., Zhu, Y., Wang, Z., Hua, S.J., Li, Z.L., Guo, W.L., Zhang, G.P., Peng, J.R.*, Jiang, L.X.* (2012) Seed Fatty Acid Reducer 35:2155-2169.acts downstream of gibberellin signalling pathway to lower seed fatty acid storage in Arabidopsis.Plant, Cell and Environment
 
18. Niu, X.B., Gao, C., Lo, L.J., Luo, Y., Meng C.M., Hong, J., Hong, W.J., and Peng, J.R.*(2012) Sec13 safeguards the integrity of the endoplasmic reticulum andorganogenesis of the digestive system in zebrafish. Developmental Biology 367:197–207.
 
19. 朱智慧,胡敏杰,常长青,彭金荣 (2012) 斑马鱼leg1直系同源基因mi-leg1在小鼠中的表达谱分析。遗传 34:1174-1180
 
20. Yang, S.L., Aw, S.Q., Chang, C.Q., Korzh, S., Korzh, V.* and Peng, J.R.* (2011) Depletion of Bhmtelevates sonic hedgehogtranscript level and increases β-cell number in zebrafish. Endocrinology 152:4706-4717.
 
21. Chang, C.Q., Hu, M.J., Zhu, Z.H., Lo, L.J., Chen, J. and Peng, J.R. (2011) liver-enriched gene 1a and 1bencode novel secretory proteins essential for normal liver development inZebrafish. PLoS ONE 6(8):e22910.
 
22. Song, S.S., Qi, T.C., Huang, H., Ren, Q.C., Wu, D.W., Chang, C.Q., Peng, W., Liu, Y.L. and Peng, J.R.*, and Xie, D.X.* (2011) The Jasmonate-ZIM domain proteins interact with theR2R3-MYB transcription factors MYB21 and MYB24 to affectjasmonate-regulated stamen development in Arabidopsis.The Plant Cell23:1000–1013.
 
23. Niu, X.B., Shi, H. andPeng, J.R.(2010) The role of mesodermal signals during liver organogenesis in zebrafish. Science China Life Science 53:455-461.
 
24. Chen, J*, and Peng J.R.* (2009) p53 isoform 113p53 in zebrafish. Zebrafish 6:389-395. (Research Review)
 
25. Peng, J.R. (2009) Gibberellin and jasmonatecrosstalk during stamen development.J. Integ. Plant Biol. 51:1064-1070. (Review)
 
26. Tao, T, and Peng J.R. (2009) Liver development in zebrafish (Danio rerio). J. Genet Genomics 36: 325-334. (Review)
 
27. Cheng, H.,Song, S.S, Xiao, L.T.,Soo, H.M., Cheng, Z.W., Xie, D.X., and Peng, J.R. (2009) Gibberellin acts through jasmonateto control the expression of MYB21, MYB24 and MYB57to promote stamen filament growth in Arabidopsis. PLoS Genetics 5:e1000440.
 
28. Chen, J.,Ng, S.M.,Chang, C.Q., Zhang, Z.H., Bourdon, J.C., Lane, D.P., and Peng, J.R. (2009) p53 isoform ∆113p53 isa p53target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes & Dev. 23:278-290.
 
29. Lo, L.J., Zhang, Z.H., Hong, N., Peng, J.R., and Hong, Y.H. (2008) 3640 Unique EST clusters from the medakatestis and their potential use for identifying conserved testicular gene expression in fish and mammals. Plos One 3:e3915
 
30. Huang, H.H., Ruan, H., Aw, M.Y., Hussain, A., Guo, L., Gao, C., Qian, F., Leung, T., Song, H.W., Kimelman, D., Wen, Z.L., and Peng, J.R. (2008) Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis. Development 135:3209-3218.
 
31. Liu, Y.M., Du, L.S., Osato, M., Teo, E.H., Qian, F., Jin, H., Zhen, F.H., Xu, J., Guo, L., Huang, H.H., Chen, J., Geisler, R., Jiang, Y.J., Peng, J.R.and Wen, Z.L. (2007) The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development. Blood 110:99-106.
 
32. Hussain A., Cao, D.N., Peng, J.R. (2007) Identification of conserved tyrosine residues important for gibberellin-sensitivity of Arabidopsis RGL2 protein. Planta 226:475-483.
 
33. Cao, D.N., Cheng, H., Wu, W., Soo, H.M., and Peng, J.R. (2006) Gibberellin mobilizes distinct DELLA-dependent transcriptomes to regulate seed germination and floral development in Arabidopsis. Plant Physiol. 142: 509–525.
 
34. Cheng, W., Guo, L., Zhang, Z.H., Soo, H.M., Wen, C.M., Wu, W., and Peng J.R. (2006) HNF factors form a network to regulate liver-enriched genes in zebrafish. Dev. Biol. 294: 482-496.
 
35. Achard, P., Cheng, H., De Grauwe, L., Decat, J., Schoutteten, H., Moritz, T., Van Der Straeten, D., Peng, J.R., Harberd, N.P. (2006) Integration of plant responses to environmentally activated phytohormonal signals. Science 311: 91-94.
 
36. Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z.H., Wen, Z.L., Lane, D.P., Peng J.R. (2005) Loss-of-function of def selectively up-regulates D113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes & Development 19: 2900-2911.
 
37. Cao, D.N., Hussain, A., Cheng, H., and Peng, J.R. (2005) Loss of function of four DELLA genes leads to light- and gibberellin-independent seed germination in Arabidopsis. Planta 223: 105-113.
 
38. Hussain, A., Cao, D.N., Cheng, H., Wen, Z.L., and Peng, J.R. (2005) Identification of conserved Ser/Thr residues important for gibberellin-sensitivity of Arabidopsis RGL2 protein. Plant Journal 44:88-99.
 
39. Qian, F., Zhen, F.H., Ong, C., Jin, S.W., Soo, H.M., Stainier, D.Y.R., Lin, S., Peng, J.R., and Wen, Z.L. (2005) Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Developmental Dynamics 233:1163-1172.
 
40. Wen, C.M., Zhang, Z.H., Ma, W.P., Xu, M., Wen Z.L., and Peng, J.R. (2005) Genome-wide identification of female-enriched genes in zebrafish. Developmental Dynamics 232:171-179.
 
41. Chen, J., Li, W.X., Xie, D.X., Peng J.R., and Ding S.W. (2004) Viral virulence protein suppresses RNAi mediated defence but upregulates the role of miRNA in host gene expression. Plant Cell 16:1302-1313. 
 
42. Cheng, H., Qin, L.Q., Lee, S.C., Fu, X.D., Richards, D.E., Cao, D.N., Luo, D., Harberd, N.P., and Peng, J.R. (2004) Gibberellin regulates Arabidopsis floral development via suppression of DELLA protein function. Development 131:1055-1064.
 
43. Hussian, A. and Peng, J.R. (2003) DELLA proteins and GA signalling in Arabidopsis. J. Plant Growth Regul. 22:134-140
 
44. Lo,J., Lee, S.C., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y.W., Ma, W.P., Wang, W.F., Wen, Z.L., and Peng, J.R. (2003) 15,000 Unique Zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome Research 13:455-466.
 
45. Peng, J.R., and Harberd, N.P. (2002) The role of GA-mediated signalling in the control of seed germination. Current Opinion in Plant Biology 5:376-381.
 
46. Lee, S.C., Cheng, H., King, K.E., Wang, W.F., He Y.W., Hussian, A., Lo, J., Harberd, N.P., and Peng, J.R. (2002) Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition. Genes & Development 16:646-658.
 
第一或共同第一作者:
47. Peng, J.R., Richards, D.E., Moritz, T., Ezura, H., Carol, P., and Harberd, N.P. (2002) Molecular and physiological characterization of Arabidopsis GAI alleles obtained in tageted Ds-tagging experiments. Planta 214:591-596.
 
48. Peng, J.R., Richards, D.E., Hartley, N.M., Murphy, G.P., Devos, K.M., Flintham, J.E., Beales, J., Fish, L.J., Worland, A.J., Pelica, F., Sudhakar, D., Christou, P., Snape, J.W., Gale, M.D., and Harberd, N.P. (1999) ‘Green revolution’ genes encode mutant gibberellin response modulators. Nature 400:256-261.
 
49. Peng, J.R., Richards, D.E., Moritz, T., Cano, A., and Harberd, N.P. (1999) Extragenic suppressors of the Arabidopsis gai mutation alter the dose-response relationship of diverse gibberellin responses. Plant Physiology 119:1199-1208.
 
50. Peng, J.R., Carol, P., Richards, D.E., King, K.E., Cowling, R., Murphy, G.P., and Harberd, N.P. (1997) The Arabidopsis GAI gene defines a signalling pathway that negatively regulates gibberellin responses. Genes & Development 11:3194-3205.
 
51. Peng, J.R. and Harberd, N.P. (1997) Gibberellin deficiency and response mutations suppress the stem elongation phenotype of phytochrome-deficient mutants of Arabidopsis. Plant Physiology 113:1051-1058. 
 
52. Peng, J.R., and Harberd, N.P. (1997) Transposon-associated somatic gai-loss sectors in Arabidopsis. Plant Science 130:181-188.
 
53. Peng, J.R, and Harberd, N.P. (1993) Derivative alleles of the Arabidopsis gibberellin-insensitive (gai) mutation confer a wild-type phenotype. Plant Cell 5:351-360.
 
54. Peng, J.R., and Sun, C. (1991) Purification and certain characteristics of a Rhamnose specific lectin in the haemolymph of Philosamiacynthiaricini. Chinese Journal of Biochemistry and Biophysics (in English) 24:279-285.
 
55. Peng, J.R., and Sun C. (1991) The dynamic changes of two lectins' activities in various tissues during different development stages of Philosamiacynthiaricini. Chinese Journal of Entomology (in Chinese) 34:135-140.
 
56. Peng, J.R., and Xu, T.S. (1990) 5-L-Oxoprolinase in Bombyxmori and the effects of juvenile hormone analogs ZR512. Chinese Journal of Entomology (in Chinese) 33:143-147.
 
 
参与作者:
57. Wang Y., Zhu, Q.F., Huang, L., Zhu, Y.Q., Chen, J., Peng, J.R., Lo, L.J.* (2016) Interaction betweenBms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human. J Genet Genomics43(7):467e469
 
58.Gong, L., Pan, X., Yuan, Z.M., Peng, J.R., Chen, J. (2016) p53 coordinates with D133p53 isoform to promotecell survival under low-level oxidative stress. Journal of Molecular Cell Biology8(1):88-90.
 
59. Feng, G.H., Long, Y., Peng, J.R., Li, Q., Cui, Z.B. (2015) Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish BMC Genomics 16:979. DOI:10.1186/s12864-015-2145-5
 
60. Gao, L., Li, D.T., Ma, K., Zhang, W.J., Xu, T., Fu, C., Jing, C.B., Jia, X.E., Wu, S., Sun, X., Dong, M., Deng, M., Chen, Y., Zhu, W.G., Peng, J.R., Wan, F.Y., Zhou, Y., Zon, I.L., Pan, W.J. (2015) TopBP1 governs hematopoietic stem/progenitor cells survival in zebrafish definitive hematopoiesis. PLoS Genet 11(7): e1005346.doi:10.1371/journal.pgen.1005346.
 
61.Shan, Y., Fang, C., Cheng, C.Y., Wang, Y., Peng, J.R., Fang, W.H. (2015) Immersioninfectionofgerm-freezebrafishwithListeriamonocytogenesinducestransientexpressionofinnateimmuneresponsegenes. Frontiers in Microbiology6:373. doi: 10.3389/fmicb.2015.00373
 
62. Gu, Q.L., Yang, X.J., Lin, L., Li, S.Y., Li, Q., Zhong S., Peng, J.R., and Cui, Z.B.* (2014) Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology 60:1929-1941.
 
63. Du, L.S., Xu, J., Li, X.L., Ma, N., Liu, Y.M., Peng, J.R.,Osato, M., Zhang, W.Q., and Wen, Z.L. (2011) Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Development138:619-629.
 
64. Chen, N.,Tong, C.,Li, D.J., Wan, J.,Yuan, X.M.,Li, X.L., Peng, J.R., and Fang W.H.(2010) Antigenic analysis of classical swine fever virus E2 glycoprotein using pig antibodies identifies residues contributing to antigenic variation of the vaccine C-strain and group 2 strains circulating in China.Virology Journal 7:378.
 
65. Li Z., Wen, C.M., Peng, J.R.,Korzh, V., Gong, Z.Y. (2009) Generation of living color transgenic zebrafish to trace somatostatinexpressing cells and endocrine pancreas organization. Differentiation 77:128-134.
 
66. Meng, C.Y., Chen, J., Ding, S.W., Peng, J.R., Wong, S.K. (2008).Hibiscus chlorotic ringspot virus coat protein inhibits trans-acting small interfering RNA biogenesis in Arabidopsis.Journal of General Virology89: 2349-2358.
 
67. Jin, B.L., Tao, Q., Peng J.R., Soo, H.M., Wu, W., Ying, J.M., Fields, C.R., Delmas, A.L., Liu, X.F., Qiu, J.X., and Robertson, K.D. (2008) DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis, and immune function. Human Molecular Genetics 17: 690-709.
 
68. Huang, H.Z., Lu, F.I., Jia, S.J., Meng, S., Cao, Y., Wang, Y.Q., Ma, W.P., Yin, K., Wen, Z.L., Peng, J.R., Rao, Z.H., Thisse, C., Thisse, B., Meng, A.M. (2007) Amotl2 is essential for cell movements in zebrafish embryo by regulating c-Src translocation. Development 134:979-988.
 
69. Gan, Y., Yu, H., Peng, J., and Broun.P.(2007) Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis.Plant Physiol. 145:1031-1042.
 
70. Meng, C.Y., Chen, J., Peng, J.R., and Wong S.M. (2006) Host-induced avirulance of Hibiscus chlorotic ringspot vitus mutants correlates with reduced silencing suppression activity. J. Gen. Virol. 87: 451-459.
 
71. Jin, H., Xu, J., Qian, F., Du, L., Tan, C.Y, Lin, Z.X., Peng, J.R., and Wen, Z.L. (2006) The 5’- zebrafish scl promoter targets transcription to the brain, spinal cord, and hematopoietic and endothelial progenitors. Developmental Dynamics 235:60-67.

72. Ren, C.M., Pan, J.W., Peng, W., Genschik, P., Hobbie, L., Hellmann, H., Estelle, M., Gao, B.D., Peng, J.R., Sun, C.Q., and Xie, D.X. (2005) Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant Journal 42:514-524.
 
 
74. Yu, H., Ito, T., Zhao, YX., Peng J.R., Kumar, P., and Meyerowitz, E. (2004) Floral homeotic genes are targets of gibberellin signaling in flower development. Proc. Natl. Acad. Sci. USA. 101:7827-7832.
 
75. Hynes, L.W., Richards, D.E., Peng J.R., and Harberd, N.P. (2003) Transgenic expression of the Arabidopsis DELLA proteins GAI and gai confers altered gibberellin response in tobacco. Transgenic Research 12:707-714.
 
76. Fu, X.D., Richards, D.E., Ait-ali T., Hynes, L.W., Ougham H., Peng, J.R., and Harberd, N.P. (2002) Gibberellin-mediated proteasome-dependent degradation of the barley DELLA-protein SLN1 repressor. Plant Cell 14:3191-3200.
 
77. Fu, X.D., Sudhakar, D., Peng, J.R., Richards, D.E., Christou, P., and Harberd, N.P. (2001) Expression of Arabidopsis GAI in transgenic rice represses multiple gibberellin responses. Plant Cell 13:1792-1802.
 
78. King, K.E, Carol P, Cowling R.J, Peng J.R., Richards D.E, et al. (2000) Genetic approaches to the understanding of gibberellin-media-ted plant growth regulation. In Molecular Approaches to the Understanding of Plant Hormones, ed. Palme, Schell.New York: Springer-Verlag.
 
79. Richards, D.E., Peng, J.R., and Harberd, N.P. (2000) Plant GRAS and metazoan STATs: one family? BioEssays 22:573-577.
 
80. Harberd, N.P., King, K.E., Carol, P., Cowling R.J., Peng, J.R., and Richards, D.E (1998) Gibberellin: inhibitor of an inhibitor of ---? BioEssays 20:1001-1008.
 
81. Carol, P., Peng, J.R., and Harberd, N.P. (1995) Isolation and preliminary characterization of gas1-1, a mutation causing partial suppression of the phenotype conferred by the gibberellin-insensitive (gai) mutation in Arabidopsis thaliana (L) Heyhn. Planta 197:414-417.
 
82. Whitelam, G.C., Jonson, E., Peng, J.R., Carol, P., Anderson, M., Cowl, J., and Harberd, N.P. (1993) Phytochrome A null mutants of Arabidopsis display a wild-type phenotype in white-light. Plant Cell 5:757-768.
 
83. Zhao, Z.A., Li, W.S., Peng, J.R., and Gu, Q.M. (1990) Partial purification and characterization of wheat bran polyphenoloxidase. Journal of Fudan University (in Chinese) 29:318-326.

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